GENETIC ALTERATIONS IN INTERVERTEBRAL DISC DISEASE

Genetic Alterations in Intervertebral Disc Disease

Background: Intervertebral disc degeneration (IVDD) is considered a multifactorial disease.The last two decades of research strongly demonstrate that genetic factors contribute about 75% of the IVDD etiology.Recent total genome sequencing studies have shed light on the various single nucleotide polymorphisms (SNPs) that are associated with IVDD.Aim

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Inhibition of EZH2 alleviates SAHA-induced senescence-associated secretion phenotype in small cell lung cancer cells

Abstract Chemotherapy has been widely used in small cell lung cancer (SCLC) treatment in the past decades.However, SCLC is easy to recur after chemotherapy.The senescence of cancer cells during chemotherapy is one of the effective therapeutic strategies to inhibit the progression of cancer.Nevertheless, the senescence-associated secretion phenotype

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Fertility Sparing Treatment in Patients With Early Stage Endometrial Cancer, Using a Combination of Surgery and GnRH Agonist: A Monocentric Retrospective Study and Review of the Literature

Objectives: To evaluate Feet Serum the efficacy and safety of gonadotropin-releasing hormone (GnRH) agonist after endometrial resection in women suffering early stage endometrial carcinoma (EC) and/or endometrial intra-epithelial neoplasia (EIN).Design: A retrospective review of clinical files between January 1999 and December 2016.Setting: Univers

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